<div id="tjbox"><ol id="tjbox"></ol></div>
    <div id="tjbox"></div>

      <div id="tjbox"><tr id="tjbox"></tr></div>

            <progress id="tjbox"><tr id="tjbox"></tr></progress>
            我的账户 7×24小时客服热线:400-829-7929 语言:
            热门产品: 原人参二醇,人参皂苷,虫草素,6-姜酚,中药成分化合物库
            产品分类
            在线咨询
            联系电话:
            销售:
            400-829-7929(7*24小时)
            028-82633397-801, 802, 803 
            028-82633860-801, 802, 803
            技术服务和产品定制:
            028-82633987
            在线服务:  
            沈帅 点击这里给我发消息 
            文静  点击这里给我发消息
            文献信息

            Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models

            期刊名:Oncotarget
            文献编号:PMC4546464
            文献地址: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546464/
            发表?#25484;冢?015 Mar 29.


            Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models

            Haibo Shao,Jian Zhang,Ziping Sun,Feng Chen,Xu Dai,Yaming Li,Yicheng Ni and Ke Xu

            Abstract

            A viable rim of tumor cells surrounding central necrosis always exists and leads to tumor recurrence after vascular disrupting treatment (VDT). A novel necrosis targeted radiotherapy (NTRT) using iodine-131-labeled hypericin (131I-Hyp) was specifically designed to treat viable tumor rim and improve tumor control after VDT in rabbit models of multifocal VX2 tumors. NTRT was administered 24 hours after VDT. Tumor growth was significantly slowed down by NTRT with a smaller tumor volume and a prolonged tumor doubling time (14.4 vs. 5.7 days), as followed by in vivo magnetic resonance imaging over 12 days. The viable tumor rims were well inhibited in NTRT group compared with single VDT control group, as showed on tumor cross sections at day 12 (1 vs. 3.7 in area). High targetability of 131I-Hyp to tumor necrosis was demonstrated by in vivo SPECT as high uptake in tumor regions lasting over 9 days with 4.26 to 98 times higher radioactivity for necrosis versus the viable tumor and other organs by gamma counting, and with ratios of 7.7–11.7 and 10.5–13.7 for necrosis over peri-tumor tissue by autoradiography and fluorescence microscopy, respectively. In conclusion, NTRT improved the anticancer efficacy of VDT in rabbits with VX2 tumors.

            Hypericin, 4,5,7,4′,5′,7′-hexahydroxy-2,2′-dimethylnaphthodianthrone (with a purity 99%; Biopurify Phytochemicals Ltd., Chengdu, China; http//www.biopurify.com)

            相关产品
            在线客服系统 345彩票是真的么
              <div id="tjbox"><ol id="tjbox"></ol></div>
              <div id="tjbox"></div>

                <div id="tjbox"><tr id="tjbox"></tr></div>

                      <progress id="tjbox"><tr id="tjbox"></tr></progress>
                        <div id="tjbox"><ol id="tjbox"></ol></div>
                        <div id="tjbox"></div>

                          <div id="tjbox"><tr id="tjbox"></tr></div>

                                <progress id="tjbox"><tr id="tjbox"></tr></progress>